Abstract
Tramadol is a centrally acting opioid analgesic structurally related to codeine and morphine. O-Alkyl, N-desmethyl, and non-phenol containing derivatives of tramadol were synthesized to probe their effect on metabolic stability and both in vitro and in vivo potency.
MeSH terms
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Analgesics, Opioid / chemistry*
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Analgesics, Opioid / metabolism
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Analgesics, Opioid / pharmacology*
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Animals
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Humans
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Microsomes, Liver / drug effects
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Microsomes, Liver / metabolism
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Molecular Structure
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Pain / drug therapy
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Protein Binding
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Rats
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Structure-Activity Relationship
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Tramadol / analogs & derivatives*
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Tramadol / chemistry
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Tramadol / metabolism
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Tramadol / pharmacology*
Substances
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Analgesics, Opioid
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Tramadol